By Tomoyoshi Nozaki, Alok Bhattacharya
This booklet records and provides new advancements within the research of amebiasis, one of many ignored tropical illnesses. approximately 50 million humans world wide are contaminated with the pathogen Entamoeba histolytica, inflicting large-scale morbidity and mortality quite in constructing nations. This booklet can help clinicians for larger analysis and administration of the ailment, researchers for starting up examine initiatives on a number of the poorly understood facets of the ailment and the pathogen, and scholars for updating their wisdom. the topics lined variety from genomics and molecular and cellphone biology to drug resistance and new drug improvement, highlighting significant advances in recent times in our knowing because of fast development in genomic and different biomedical applied sciences, resembling visualization of molecular methods. many of the chapters supply contemporary info in line with most up-to-date courses. a couple of chapters describe a number of the severe methodological matters that might be useful for college students and researchers drawn to entering into the sphere. The contributing authors comprise just about all the energetic researchers and clinicians from worldwide. This ebook should be an invaluable fundamental fabric and a useful resource of data for a person attracted to realizing amebiasis, its analysis, and therapy. it's going to even be invaluable to people who have an interest in studying in regards to the biology of early branching eukaryotes and protist pathogens.
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Additional info for Amebiasis: Biology and Pathogenesis of Entamoeba
45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. D.
The genome of the axenized Laredo strain of E. moshkovskii (originally derived from a human infection) has been sequenced using 454 sequencing technology. The genome assembly is currently available via amoebaDB and covers approximately 23 million base pairs in 1,147 scaffolds. The reptile parasite Entamoeba invadens is more distantly related to E. histolytica. It is primarily studied as a model for the process of cyst formation because, in contrast to E. histolytica, it can be induced to encyst in axenic laboratory culture.
The E. histolytica genome was sequenced before the arrival of second-generation sequencing technology. This technology has had a transformative effect on many areas of biology by allowing rapid sequencing of entire genomes or transcriptomes. The technologies work by parallelizing the sequencing process so that millions of short sequences can be determined simultaneously. Rapid improvements in performance and reductions in cost mean that whole genome sequencing may become as commonplace as polymerase chain reaction (PCR) in the near future.